Hydrocodone and acetaminophen are regarded to generally be significantly excreted with the kidney, and the potential risk of adverse reactions to this drug might be larger in patients with impaired renal operate.
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Concomitant use of hydrocodone bitartrate and acetaminophen tablets with CYP3A4 inducers or two discontinuation of an CYP3A4 inhibitor could lessen hydrocodone plasma concentrations, lessen opioid efficacy or, possibly, produce a withdrawal syndrome inside a patient who had developed physical dependence to hydrocodone.
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Inform individuals to stop getting hydrocodone bitartrate and acetaminophen tablets even though applying any medicines that inhibit monoamine oxidase. People must not start off MAOIs though using hydrocodone bitartrate and acetaminophen tablets [see DRUG INTERACTIONS].
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Hydrocodone is a complete opioid agonist with relative selectivity for the mu-opioid (μ) receptor, although it can connect with other opioid receptors at bigger doses. The principal therapeutic action of hydrocodone is analgesia.
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Advise people and caregivers that probably deadly additive results may possibly occur if hydrocodone bitartrate and acetaminophen tablets are utilized with benzodiazepines and also other CNS depressants, together with Liquor, instead of to employ these concomitantly Except supervised by a healthcare supplier [see WARNINGS, DRUG INTERACTIONS].
Hydrocodone bitartrate and acetaminophen tablets could induce critical hypotension including orthostatic hypotension and syncope in ambulatory clients. There is improved risk in clients whose capability to maintain blood pressure level has already been compromised by a diminished blood volume or concurrent administration of sure CNS depressant medication (e.g., phenothiazines or normal anesthetics) [see DRUG INTERACTIONS].